Course code Vete6039

Credit points 1

Pharmacology, Pharmacotherapy and Toxicology III

Total Hours in Course40

Number of hours for lectures10

Number of hours for seminars and practical classes10

Independent study hours20

Date of course confirmation22.11.2017

Responsible UnitClinical Institute

Course developers

author prof.

Līga Kovaļčuka

Dr. med. vet.

author lect.

Laura Voiko

Professional programme(līm.)

author lect.

Jana Vanaga

Professional programme(līm.)

Prior knowledge

Vete4023, Small Animal Surgery I

Vete4024, Small Animal Surgery II

Vete4078, Internal Medicine, Herd Health I

Vete4098, Small Animal Internal Medicine I

Vete4099, Small Animal Internal Medicine II

Vete4105, Pharmacology, Pharmacotherapy and Toxicology I

Vete4109, Internal Medicine, Herd Health II

Vete4110, Clinical and Laboratory Diagnostics I

Vete4111, Clinical and Laboratory Diagnostics II

Vete4112, Surgery Techniques and Topographical Anatomy I

Vete4113, Surgery Techniques and Topographical Anatomy II

Vete6040, Internal Medicine, Herd Health III

Course abstract

The aim of study course “Pharmacology, Toxicology and Clinical pharmacotherapy III” Clinical pharmacotherapy is to acquire in depth, science based knowledge about the drug usage protocols and tactics in animals, drug interactions and combinations, adverse effects and official reporting principles.

Learning outcomes and their assessment

• Knowledge of drug interactions, side effects and legal aspects and responsibly in accordance with relevant legislation and drug usage – two tests.
• Skills - be able to understand and prescribe drugs from different pharmacology groups, taking into account individual animal factors, potential drug interaction and clinical disease factors according to guidelines – practical’s, calculations, tasks.
• Competence – to apply the acquired knowledge in the clinical case interpretation and in animal practical treatment by using drug guidelines and principles of rational use of drugs - KEGA.

Course Content(Calendar)

1.Drug adverse reactions, current legislation. 1 hour lecture.
Practical adverse drug reporting. 1 hour seminar.
2.Pharmacology of drug combinations. 1 hour lecture.
Clinical aspects of fluid therapy. 1 hour seminar.
3.Guidelines for rational use of antiseptics and antimicrobial agents. 1 hour lecture and 1 hour seminar.
4.Principles and guidelines for the selection of non-steroidal anti-inflammatory drugs in healthy animals and animals with liver, kidney disease. 1 hour lecture and 1 hour seminar.
Test: Adverse drug reactions, combinations, interactions, antibiotic usage guidelines.
1.Pharmacotheraphy principles in small animal medicine. 2 hours lecture and 2 hours seminar.
2.Pharmacotheraphy principles in horse and productive animal medicine. 2 hours lecture.
3.Principles of treating skin, eye and ears disease, 1 hour lecture.
4.Principles of drug usage in newborns, gerontologic, lactating and pregnant animals, 1 hour lecture.
Final Seminar - Clinical Case Study (KEGA) presentation and test 4 hours.
Test: Principles of treating skin, eye and ears disease, non-steroidal anti-inflammatory drug and glucocorticoid use guidelines.

Requirements for awarding credit points

Two tests, mark 5 at least and Clinical and epidemiological case analysis work (KEGA) should be l successfully passed.
Lecture, seminar attendance 70%, study report on the topic for a missed lesson. If more than 30 % missed attendance and no topics prepared, study course should be repeated.

Description of the organization and tasks of students’ independent work

KEGA aims to learn how to analyze, develop and interpret an individual clinical case treatment plan, protocol. At the beginning of the study course students are given a clinical case description, which is obtained from the database of clinical cases of the Veterinary Clinic of the LUA, in consultation with the course lecturer. The task of the student is to compile and analyze the clinical case treatment protocol, prepare a personalized approach to the treatment protocol, analyze the information available on information sources.
At the beginning of the work, a clinical record of the clinical case should be made, based on the record of the protocol developed by the Veterinary Clinic of Latvia University of Agriculture. Record must be electronically sent to the responsible academic staff. If the description is correct, the academic staff authorizes the student to start preparing an extended pharmacotherapy plan byanalysing drugs used and their interactions. If the description reveals significant inconsistencies, then the student should improve it and re-submit it.
The analysis of a clinical case should be prepared methodically according to the rules developed by the LUA VMF Teaching Methodology Commission. The analysis should include the following sections: title page, introduction, theoretical part, conclusions, recommendations, literature used. The theoretical part should include the following information:
1. Short description of the disease, description of the diagnosis, including the causes of the disease, aetiology, epizootiology, pathogenesis, clinical signs, diagnostics.
2. Pharmacotherapeutic plan including the principles of choice of medicinal products, indications, contraindications, side effects, restrictions on use,
3. Interaction of the drugs used in pharmacotherapy.

KEGA's work must be submitted to the lecturers at least two weeks before the planned defense.
The defense of KEGA is carried out orally, during practical classes. The oral defense time per student is up to 10 minutes. The student should be able to analyze the illness, the pharmacotherapy plan and the possible drug interactions and therapy. Students are informed about the course of defense with details of the defense process.
KEGA assessment is based on the following criteria:
1. Analysis of the clinical case and pharmacotherapy plan
2. A written KEGA analysis.
3. Oral presentation - visual presentation, content, ability to answer questions.

Criteria for Evaluating Learning Outcomes

Student skills are evaluated in accordance with the procedures specified in the tasks of the laboratory work. Tests of the study course and the work of KEGA are evaluated in accordance with the criteria of the 10-point system scale indicated in the LLU Study Regulations. A test result is accepted from 5 points. Tests and KEGA must be evaluated with a successful grade.
If KEGA is not developed at the set time, student arrange an individual time with academic staff for an additional time development.
1. Adverse drug reactions, combinations, interactions, guidelines for antibiotic use.
2. Principles of drug use for the treatment of the ears, eyes, skin, non-steroidal anti-inflammatory drugs, glucocorticoid use guidelines.

Compulsory reading

1.Plumb D.C. Veterinary Drug Handbook. USA: Pharma Vet. Publ., 2008. 1485 p.
2. Plumb D.C. Plumb's veterinary drug handbook. 8th edition. Stockholm, Wisconsin: PharmaVet Inc., 2015. 1279 p.
3. Veterinary Pharmacology and Therapeutics., edited by Jim E. Riviere and Mark G. Papich. 10th edition. Hoboken, NJ: John Wiley & Sons Inc., 2018.

Further reading

1. Plumb D.C. Veterinary Drug Handbook. USA: Pharma Vet. Publ., 2008. 1485 p.

Periodicals and other sources

1.Journal of Veterinary Pharmacology and Therapeutics. J Vet Pharmacol Therapeut. Published by John Wiley and Sons. ISSN (printed): 0140-7783. ISSN (electronic): 1365-2885.



Compulsory course of study programme Veterinary medicine.