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Pharmaceutic Pharmacology

Course developer

Prior knowledge

VeteD053, Veterinary pharmacology and toxicology

VeteT001,

Course abstract

The aim of the course is to acquaint doctoral students with the pharmaceutical pharmacology approach in the process of studying the development of new medicines and their molecular mechanism of action.
Doctoral students have to known the molecular mechanisms of the operation of medicinal products of various therapeutic pharmacological groups, the components of the exhibition process of new medicinal products in order to explain at the molecular level the pharmacokinetic, pharmacodynamic and substance interaction principles related to the use of the drug, as well as the causes of side effects and toxic effects.

Learning outcomes and their assessment

Knowledge: After successful completion of the requirements of the study subject, the student will be able to demonstrate that he or she is familiar with the most current scientific theories that will allow: To evaluate and justify the principles of operation of medicinal products of various therapeutic pharmacological groups, to base on understanding of their molecular mechanisms of action; Explain at the molecular level the pharmacokinetic, toxic and substance interaction principles associated with the use of the medicinal product, Understand the stages of the exhibition process of new medicinal products and project planning.
Skills: Upon successful completion of the course, students will be able to: ustify the molecular mechanisms of therapeutic efficacy of the medicinal product and the associated pharmacokinetic, pharmacodynamic and substance interaction principles. Use the latest experimental research methods in the development of new drugs.
Competence: Upon successful completion of the course, students will be able to: Independently solve research problems and plan scientific projects in the field of Pharmaceutical Pharmacology.

Evaluation – doctoral exam.

Course Content(Calendar)

A doctoral student with independent study of scientific literature must learn about:
1. The process of discovering and developing new medicines today.
2. The concept of pharmacoeconomics.
3. Pharmacokinetics, the use of different forms of drug substances to improve the effectiveness of the drug.
4. Principles of metabolism of drug substances. The concept of pharmacogenomics and personalized medicine. Pharmacodynamics, dose-effect relationships, basic principles of experimental data processing.
5. Molecular objectives of drug substances (validation and examples of medicinal products of different therapeutic pharmacological groups):
6. Enzymes Membrane transporters, Potential - sensitive ion channels,
7. Ligands - sensitive ion channels,
8. Receptors with enzyme activity, Ion channels associated with cytosol enzymes, G-protein receptors, Kernel receptors.
9. Experimental research methods of drug substances: in silico (camometry, proteometrics, molecular computer modeling methods); in vitro (cell and tissue cultures, biochemical measurements, receptor-ligand binding studies, evaluation of gene and protein expression); in vivo (experimental models for cardiovascular, CNS and inflammatory-analgesic studies).

10. Use of experimental animals in the development of new drugs: ethical principles, alternative methods, submission of an experimental application to the responsible institutions in Latvia and the EU.

Requirements for awarding credit points

Passed Promotion Exam in the direction of the research
2 weeks before the exam, doctoral student must submit an application to the Study Center.

Description of the organization and tasks of students’ independent work

The doctoral student independently studies scientific literature on the topics specified in the study course plan and prepares for the promotion exam.

Criteria for Evaluating Learning Outcomes

Passed Promotion Exam at the approved commission.
The exam is done by choosing a ticket (with at least 2 questions) and orally.

Compulsory reading

1. Fiona Cunningham et al., Comparative and veterinary Pharmacology – 2012 Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 348 p. ISBN10 364226297X
2. Kevin Woodward, Veterinary Pharmacovigilance : Adverse Reactions to Veterinary Medicinal Products: Wiley-Blackwell , 2009; 776 p.
3. Jim E. Reviere. Comparative Pharmacokinetics : Principles, Techniques and Applications, Iowa State university press, 2011, 376 p.
Literatūras saraksts –
4. Rang&Dale's Pharmacology, 7th Edition. Churchill Livingstone, 2007, 844 lpp.

5. Goodman&Gilman, The Pharmacological basis of therapeutics 11th ed., McGraw Hill Publishing, 2005, 1984 lpp.

Further reading

1. Arturo Anadon. Perspectives in Veterinary Pharmacology and Toxicology, Front Vet.Sci, 2016;3:82.
2. Purviņš I., Purviņa S. Praktiskā farmakoloģija. 3.papildinātais izdevums, 2002, 794 lpp.

3. Lejnieks A., u.c. Klīniskā medicīna I. Medicīnas apgāds, 2010, 942 lpp.

Periodicals and other sources

1. Journal of Veterinary Pharmacology and Therapeutics Edited By: Paul Mills, Katrina Mealey, Manfred Kietzmann and Mark Papich, Online ISSN:1365-2885, © John Wiley & Sons Ltd.
2. Journal of Clinical Toxicology. Longdom Group SA, ISSN:2161-0495.
3. Receptoru klasifikācija un reģistrs: http://www.iuphar-db.org/index.jsp.

4. Zāļu reģistrs: http://www.zva.gov.lv/index.php?id=377&sa=377&top=112.

Notes

Doctoral study programme Veterinary Medicine.