Course code Vete4105

Credit points 4

Pharmacology, Pharmacotherapy and Toxicology I

Total Hours in Course160

Number of hours for lectures48

Number of hours for seminars and practical classes32

Independent study hours80

Date of course confirmation22.11.2017

Responsible UnitClinical Institute

Course developers

author Klīniskais institūts

Līga Kovaļčuka

Dr. med. vet.

author Klīniskais institūts

Laura Voiko

Professional programme(līm.)

Prior knowledge

Biol1003, Botany and Pharmacognosy

Ķīmi1028, Inorganic Chemistry

Ķīmi3004, Biochemistry

Ķīmi3016, Organic Chemistry

Vete1001, Latin Language I

Vete1002, Latin Language II

Vete2013, Anatomy of the Domestic Animals I

Vete2014, Anatomy of the Domestic Animals II

Vete2015, Anatomy of the Domestic Animals III

Vete6022, Physiology I

Vete6023, Physiology II

Course abstract

The aim of the special study course Pharmacology, Toxicology and Clinical pharmacotheraphy I (Pharmacology) is to acquire in depth knowledge about drug prescription, drug forms and routes of drug administration, basics of pharmacodinamics and pharmacokinetics of the drugs used animal therapy; in special pharmacology to acquire knowledge about different drug groups, drug indications, contraindications and principles of drug usage in different animal species.

Learning outcomes and their assessment

*Knowledge of the drug forms and understanding of drug administration routes, organism system drug pharmacology, pharmacodynamics, pharmacokinetics, side effects. Acquired knowledge and skills of veterinary drug prescription and storage, according to legislation. Legislation and guidelines on responsible use of drugs (seminars, one test).
*Skills by summarizing all legislation prescribe drugs from different veterinary pharmacology groups, to find and analyze the information about veterinary drugs from different organ system drug groups – their indications, contraindications and side effects by following the guidelines of European Union industry organizations. Analyze and calculate drug doses for a specific patient (laboratory work, tasks, homework, tests).

*Competence to apply the acquired knowledge in the future studies, especially in clinical subjects. Analyze and develop a proper and reasonable treatment strategy for various organ systems, drugs including antibiotics, analgesics, anesthetics), selecting the appropriate drug form and administration to animals.

Course Content(Calendar)


Course distribution by weeks (one week: 3 lectures and 2 laboratory works):
1. General veterinary pharmacology (lecture).
Drug storage, managment (laboratory work).
2. Drug forms, routes of administration (lecture).
Drug administration simulations (laboratory work).
3. Basic principles of official veterinary medicine prescription (lecture).
Drug dosage, usage calculations (laboratory work).
4. Antiparasitic drugs (lecture).
Choice of antiparasitic drugs (laboratories).
Test: Introduction, Dosage Forms, Routs of Administration, Prescription.
5. Antiseptics and disinfectants (lecture).
Phytotherapy (laboratory works).
6. Antibacterial agents (lecture).
Comparison of groups of antibacterial agents, case analysis (laboratory works).
Tests: Antiparasitic, antiseptics.
7. Antibacterial agents (lecture).
Comparison of groups of antibacterial agents, case analysis (laboratory works) ..
8. Neurotropic agents (lecture).
Analysis of antiepileptic drugs, monitoring plan (laboratory work).
9. Drugs affecting the nervous system (lecture).
Clinical cases - optimal selection of anesthesia protocol (laboratory work).
10. Non-steroidal anti-inflammatory drugs (lecture).
Long-term NSAID use (laboratory work).
Test: Nervous system pharmacology, anesthetics.
11. Anti-inflammatory drugs (lecture).
Physiological substitution. Topical formulations of anti-inflammatory drugs (laboratory work).
Test: Antibiotics.
12. Pharmacology of the Gastrointestinal system (lecture).
Grouping of agents affecting the Gastrointestinal system (laboratory work).
Test: Non-steroidal anti-inflammatory drugs, glucocorticoids.
13. Pharmacology of the Gastrointestinal system (lecture).
Grouping of agents affecting the Gastrointestinal system (laboratory work).
14. Pharmacology of the genitourinary system (lecture).
Examination of agents affecting the reproductive system (laboratory work).
15. Pharmacology of the respiratory system (lecture).
Review of asthma medications (laboratory work).
16. Cardiovascular system pharmacology (lecture).
Grouping of agents affecting the cardiovascular system (laboratory work).
Test: Digestive and respiratory system drugs.

Requirements for awarding credit points

Final exam (5th semester). Type of examination - oral answer exam of 3 ticket questions, writing a prescription for one of the drug included in the ticket questions.
A student is admitted to the exam if
1. Successfully passed (5 points) 6 tests.
2. Attended lectures, at least 70%, prepared a report on missed classes. If more than 30% of lectures and laboratory work are unjustifiably missed and a report of the missed classes is not submitted, the course must be re-acquired.
3. Independent works submitted and group works defended.
The examination can be taken twice, the third time with a commission approved by the Clinical Institute.

Description of the organization and tasks of students’ independent work

During the course, the student must prepare several homeworks on topics: herbal drugs, antibacterials, non-steroidal anti-inflamatory, antiparasitic, cardiovascular drugs. Homework is organized as a student's independent study, preparation of summaries, analysis, which must be submitted to the lecturer within 2 weeks from the announcement of the task.

Criteria for Evaluating Learning Outcomes

Students' skills are evaluated according to the procedures set in the laboratory tasks.
Tests and home works are evaluated according to the 10-point system scale criteria specified in the Study Regulations of the Latvia University of Agriculture. Test is credited evaluated from 5 points.
Tests of the study course:
1. Introduction, dosage forms, types of administration, drug prescription.
2. Antiparasitic, antiseptic drugs.
3. Antibiotics.
4. Pharmacology of the nervous system drugs, anesthetics.
5. Non-steroidal anti-inflammatory drugs, glucocorticoids.
6. Digestive and respiratory system drugs.

Compulsory reading

1. Veterinary Pharmacology and Therapeutics., Edited by Nicholas H. Booth, Leslie E. McDonald. - 7-th Edtion. -Iowa State University Press., Ames, 1995. - 1180 p.
2. Small Animal Clinical Pharmacology & Therapeutics., Edited by Dawn Merton Boothe., 2ng edition, Elsvier, 2012. – 1334.

3. Veterinary Drug Handbook. Donald C. Plumb.- Pharma Vet. Publ., USA, 2008.- 1485 p.

Compulsory reading

Veterinary Pharmacology and Therapeutics., Edited by Nicholas H. Booth, Leslie E. McDonald. - 7-th Edtion. -Iowa State University Press., Ames, 1995. - 1180 p.
Small Animal Clinical Pharmacology & Therapeutics., Edited by Dawn Merton Boothe., 2ng edition, Elsvier, 2012. – 1334.
Veterinary Drug Handbook. Donald C. Plumb.- Pharma Vet. Publ., USA, 2008.- 1485 p.

Further reading

1. Basic and Clinical Pharmacology/ Bertram G.Katzung. 4-th Edition.- California, 1989. p. 897.

2. Veterinary Drug Handbook. Donald C. Plumb.- Pharma Vet. Publ., USA, 2008.- 1485 p.

Periodicals and other sources

1. Journal of Veterinary Pharmacology and Therapeutics, Wiley Online Library.
2. http://cliniciansbrief.com

Notes

Compulsory course of study programme Veterinary medicine.