Course code InfT5045

Credit points 2

Modelling of Biosystems

Total Hours in Course80

Number of hours for lectures12

Number of hours for laboratory classes12

Independent study hours56

Date of course confirmation12.01.2016

Responsible UnitDepartment of Computer Systems

Course developer


Egils Stalidzāns

Dr. sc. ing.

Course abstract

Development of a model and it’s application are important skills in modern biotechnology, medicine and ecology. The course covers the cycle of model development and analysis including the development of model structure as well as determination of model parameters under information insufficiency. Models of different scales – from cellular till population scale are used as case studies.

Learning outcomes and their assessment

As a result of learning this course students acquire:
• knowledge about realisation of main steps in development of computer models in accordance to the recent scientific achievements extracting maximal amount of information from available experimental data and literature;
• skills to justify choice of appropriate modelling technology depending on the available amount of information, skills to compare and critically analyse different literature sources;
• competence formulate and critically assess alternative modelling strategies, create new and improve existing modeling approaches in order to improve the performance of different bioprocesses.

Compulsory reading

1. Palsson B.O. Systems Biology: Properties of Reconstructed networks. Cambridge: Cambridge University Press, 2006.
2. Ingalls B.P. Mathematical Modeling in Systems Biology. Massachuset: Massachusets Institute of Technology, 2013.
3. Selga T. Šūnu bioloģija. LU Akadēmiskais apgāds. Rīga, 2007.
4. Jones D.S., Sleeman B.D. Differential Equations and Mathematical Biology. Chapman &Hall/CRC, 2003.

Further reading

1. Szallasi Z., Stelling J., Periwal V. System Modelling in Cell Biology from concepts to nuts and bolts, MIT Press, 2006.